1245904-28-2Relevant academic research and scientific papers
Monofluorinated aziridines in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines
Konev,Abbaspour Tehrani,Khlebnikov,Novikov,Magull
experimental part, p. 976 - 986 (2010/10/21)
Nonracemic C-fluoroaziridines were synthesized for the first time by reaction of fluorocarbene with N-diphenylmethylidene-substituted natural amino acid esters. The products were shown to be used in asymmetric synthesis of chiral fluorinated prop-2-yn-1-amines via one-pot process involving isomerization of 2-fluoroaziridines into α-fluoro imines and subsequent reaction with alkynyldifluoroborane generated in situ.
