1245904-83-9Relevant academic research and scientific papers
Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors
Ling, Cui,Zheng, Zhibing,Jiang, Xian Cheng,Zhong, Wu,Li, Song
scheme or table, p. 5123 - 5125 (2010/10/19)
Based on a homology-modeled structure of PLTP and characteristic structural features of reported cholesteryl ester transfer protein (CETP) inhibitors, we designed and synthesized a novel series of 2,4,5-trisubstituted selenazole compounds. Biological evaluation reveals that compounds 12 and 17 exhibit favorable PLTP activity, and their IC50s are 8 μM and 10 μM, respectively.
