1245905-92-3Relevant academic research and scientific papers
Organocatalytic asymmetric synthesis of trifluoromethyl-substituted diarylpyrrolines: Enantioselective conjugate cyanation of β-aryl-β- trifluoromethyl-disubstituted enones
Kawai, Hiroyuki,Okusu, Satoshi,Tokunaga, Etsuko,Sato, Hiroyasu,Shiro, Motoo,Shibata, Norio
supporting information; experimental part, p. 4959 - 4962 (2012/06/30)
Ether way: The cinchona-alkaloid-catalyzed title reaction was achieved in high yields with high to excellent ee values for the first time, and affords key intermediates for the biologically important 2 having a trifluoromethylated all-carbon quaternary chiral center. Ether-type catalysts (1) are more efficient in this transformation than the conventional hydroxy analogues. Copyright
