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1245907-05-4

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1245907-05-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1245907-05-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,9,0 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1245907-05:
(9*1)+(8*2)+(7*4)+(6*5)+(5*9)+(4*0)+(3*7)+(2*0)+(1*5)=154
154 % 10 = 4
So 1245907-05-4 is a valid CAS Registry Number.

1245907-05-4Downstream Products

1245907-05-4Relevant academic research and scientific papers

3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors

Ando, Ryoichi,Ikegami, Hiroshi,Sakiyama, Makoto,Ooike, Shinsuke,Hayashi, Masayuki,Fujino, Yasuhiro,Abe, Daisuke,Nakamura, Hideo,Mishina, Tadashi,Kato, Harutoshi,Iwase, Yumiko,Tomozane, Hideo,Morioka, Masahiko

, p. 4709 - 4711 (2010)

A new class of Aurora A kinase inhibitor was created by transforming 4-(5-methyl-3-pyrazoloamino)pyrimidine moiety of VX-680 to 3-cyano-6-(5-methyl- 3pyrazoloamino)pyridine. Compound 6 exhibited a potent Aurora A kinase inhibitory activity, excellent selectivity to Aurora B kinase and other 60 kinases, good cell permeability and good PK profile. Therefore compound 6 was effective in antitumor mice model at a dose of 30 mg/kg po qd without decrease of body weight.

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