1245920-23-3Relevant academic research and scientific papers
Cationic cyclization of 2-alkenyl-1,3-dithiolanes: Diastereoselective synthesis of trans-decalins
Goncalves, Sylvie,Santoro, Stefano,Nicolas, Marc,Wagner, Alain,Maillos, Philippe,Himo, Fahmi,Baati, Rachid
experimental part, p. 3274 - 3285 (2011/06/25)
An unprecedented and highly diastereoselective 6-endo-trig cyclization of 2-alkenyl-1,3-dithiolanes has been developed yielding trans-decalins, an important scaffold present in numerous di- and triterpenes. The novelty of this 6-endo-trig cyclization stan
Diastereoselective formal total synthesis of (±)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane
Goncalves, Sylvie,Hellier, Paul,Nicolas, Marc,Wagner, Alain,Baati, Rachid
supporting information; experimental part, p. 5778 - 5780 (2010/10/03)
A concise and diastereoselective formal total synthesis of triptolide, a natural product with a wide range of biological properties, is described. The key reaction is an unprecedented 6-endo-Trig cationic cyclization of a 2-alkenyl-1,3-dithiolane precursor induced by TMSOTf as Lewis acid.
An efficient one-pot four-step domino reaction for the synthesis of C2-substituted 3-methylcyclohex-2-enones
Goncalves, Sylvie,Maillos, Philippe,Nicolas, Marc,Wagner, Alain,Baati, Rachid
experimental part, p. 7856 - 7860 (2010/11/18)
An efficient one-pot four-step domino reaction of substituted β-ketoesters has been optimized giving rise to a large panel of C2-substituted 3-methylcyclohex-2-enones, an important scaffold for the preparation of various initiators for cationic or radical cyclizations. The developed methodology is quite general and applicable to a wide range of β-ketoester substrates, allowing the introduction of various functionalities at the C2 position of the 3-methylcyclohex-2-enones, in good to excellent yields.
