1245926-99-1Relevant academic research and scientific papers
Radical reduction of epoxides using a titanocene(III)/water system: Synthesis of β-deuterated alcohols and their use as internal standards in food analysis
Jimenez, Tania,Campana, Araceli G.,Bazdi, Btissam,Paradas, Miguel,Arraez-Roman, David,Segura-Carretero, Antonio,Fernandez-Gutierrez, Alberto,Oltra, J. Enrique,Robles, Rafael,Justicia, Jose,Cuerva, Juan M.
experimental part, p. 4288 - 4295 (2010/10/21)
We describe a comprehensive study into the Cp2TiCl-mediated reductive epoxide ring opening using either water as a hydrogen source or deuterium oxide as a deuterium source. The remarkable chemical profile of this reaction allows access to alcohols with anti-Markovnikov regiochemistry from different epoxides. The use of D2O as a deuterium source leads to an efficient synthesis of β-deuterated alcohols, including a deuterated sample of tyrosol, a bioactive compound contained in the leaves of the olive, which was successfully applied as an internal standard in food analysis.
