1245941-02-9Relevant academic research and scientific papers
Gene expression enabling synthetic diversification of natural products: Chemogenetic generation of pacidamycin analogs
Roy, Abhijeet Deb,Grueschow, Sabine,Cairns, Nickiwe,Goss, Rebecca J. M.
, p. 12243 - 12245 (2010)
Introduction of prnA, the halogenase gene from pyrrolnitrin biosynthesis, into Streptomyces coeruleorubidus resulted in efficient in situ chlorination of the uridyl peptide antibotic pacidamycin. The installed chlorine provided a selectably functionalizable handle enabling synthetic modification of the natural product using mild cross-coupling conditions in crude aqueous extracts of the culture broth.
