1245947-76-5Relevant academic research and scientific papers
Rapid formation of hindered cores using an oxidative prins process
Andrez, Jean-Christophe,Giroux, Marc-Andre,Lucien, Jessica,Canesi, Sylvain
, p. 4368 - 4371 (2010)
Figure Presented. An unprecedented oxidative Prins transformation on phenol derivatives mediated by a hypervalent iodine reagent has been developed. This method allows a rapid access to highly substituted compact systems present in several natural products via a carbon-based addition on an aromatic core. Substitution at each ring position has been demonstrated, enabling synthesis of molecules with up to two contiguous quaternary carbon centers in good yield.
