1246010-63-8Relevant academic research and scientific papers
Synthesis of optically active, unnatural α-substituted glutamic acid derivatives by a chiral calcium-catalyzed 1,4-addition reaction
Tsubogo, Tetsu,Kano, Yuichiro,Ikemoto, Koki,Yamashita, Yasuhiro,Kobayashi, Sh
, p. 1221 - 1225 (2010)
The first catalytic asymmetric 1,4-addition reactions of azlactones with acrylic esters have been developed. A chiral coordinative calcium catalyst was found to be effective for these reactions, and the desired 1,4-adducts were obtained in good yields and enantioselectivities. The product was converted to the corresponding α-alkylated glutamic acid by acid hydrolysis.
