1246025-16-0Relevant academic research and scientific papers
Enantioselective synthesis of substituted indoles through zirconium(IV)-catalyzed Friedel-Crafts alkylation
Blay, Gonzalo,Fernandez, Isabel,Pedro, Jose R.,Vila, Carlos
, p. 3590 - 3594 (2013/02/22)
The chiral complex of (R)-3,3-BrBINOL and zirconium tert-butoxide catalyzes the Friedel-Crafts alkylation of indoles with enones bearing an alkyl or fluorinated group at the β-position to give indoles having a side chain at the C3 position with a tertiary
Synthesis of functionalized indoles with a trifluoromethyl-substituted stereogenic tertiary carbon atom through an enantioselective Friedel-Crafts alkylation with β-trifluoromethyl-α,β-enones
Blay, Gonzalo,Fernandez, Isabel,Munoz, M. Carmen,Pedro, Jose R.,Vila, Carlos
supporting information; experimental part, p. 9117 - 9122 (2010/09/15)
Chiral complexes of BINOL-based ligands with zirconium tert-butoxide catalyze the Friedel-Crafts alkylation reaction of indoles with β-trifluoromethyl-α,β-unsaturated ketones to give functionalized indoles with an asymmetric tertiary carbon center attached to a trifluoromethyl group. The reaction can be applied to a large number of substituted α-trifluoromethyl enones and substituted indoles. The expected products were obtained with good yields and ees of up to 99%.
