1246036-80-5Relevant academic research and scientific papers
Structure and activity relationships of tartrate-based TACE inhibitors
Li, Dansu,Popovici-Muller, Janeta,Belanger, David B.,Caldwell, John,Dai, Chaoyang,David, Maria,Girijavallabhan, Vinay M.,Lavey, Brian J.,Lee, Joe F.,Liu, Zhidan,Mazzola, Rob,Rizvi, Razia,Rosner, Kristin E.,Shankar, Bandarpalle,Spitler, Jim,Ting, Pauline C.,Vaccaro, Henry,Yu, Wensheng,Zhou, Guowei,Zhu, Zhaoning,Niu, Xiaoda,Sun, Jing,Guo, Zhuyan,Orth, Peter,Chen, Shiying,Kozlowski, Joseph A.,Lundell, Daniel J.,Madison, Vincent,McKittrick, Brian,Piwinski, John J.,Shih, Neng-Yang,Shipps Jr., Gerald W.,Siddiqui, M. Arshad,Strickland, Corey O.
scheme or table, p. 4812 - 4815 (2010/10/02)
The syntheses and structure-activity relationships of the tartrate-based TACE inhibitors are discussed. The optimization of both the prime and non-prime sites led to compounds with picomolar activity. Several analogs demonstrated good rat pharmacokinetics
