1246066-69-2Relevant academic research and scientific papers
8-Bromocaffeine (8-BC): A new versatile reagent for conversion of aldoximes into nitriles
Soltani Rad, Mohammad Navid,Behrouz, Somayeh,Nekoei, Abdo-Reza
, p. 1191 - 1198 (2012)
A rapid and highly convenient synthesis of nitriles from the corresponding aldoximes using 8-bromocaffeine (8-BC) is described. In this protocol, aldoximes react with 8-BC in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and N,N-dimethylformamide (DMF) to furnish the corresponding nitriles under both microwave-assisted and/or conventional heating (reflux) conditions in short times and in good to excellent yields. This methodology is highly efficient for structurally diverse aldoximes including aliphatic, aromatic, and heteroaromatic oximes. Georg Thieme Verlag Stuttgart · New York.
Simple and highly efficient procedure for conversion of aldoximes to nitriles using N-(p-Toluenesulfonyl) imidazole
Rad, Mohammad Navid Soltani,Khalafi-Nezhad, Ali,Behrouz, Somayeh,Amini, Zohreh,Behrouz, Marzieh
experimental part, p. 2429 - 2440 (2010/09/05)
A facile and efficient method for dehydration of aldoximes into nitriles using N-(p-toluenesulfonyl) imidazole (TsIm) is described. In this method, aldoximes were refluxed with TsIm in the presence of 1,8-diazabicyclo-[5.4.0] undec-7-ene (DBU) in dimethylformamide (DMF) to afford the corresponding nitriles in good yields. This methodology is highly efficient for various structurally diverse aldoximes including aromatic, heteroaromatic, and aliphatic oximes. A plausible mechanism for the conversion of aldoxime into nitriles using TsIm/DBU is explained. Copyright Taylor & Francis Group, LLC.
