1246078-58-9

Basic information

• Product Name: N-((1R)-(5-(2-bromo-5-fluorophenyl)-1-tert-butyl-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide
• Synonyms: N-((1R)-(5-(2-bromo-5-fluorophenyl)-1-tert-butyl-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide
• CAS NO: 1246078-58-9
• Molecular Weight: 575.425
• Mol File: 1246078-58-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((1R)-(5-(2-bromo-5-fluorophenyl)-1-tert-butyl-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1R)-(5-(2-bromo-5-fluorophenyl)-1-tert-butyl-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide(1246078-58-9)
• EPA Substance Registry System: N-((1R)-(5-(2-bromo-5-fluorophenyl)-1-tert-butyl-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide(1246078-58-9)

Safety Data

• Hazardous Substances Data: 1246078-58-9(Hazardous Substances Data)

Upstream product

• 959996-58-8 6-(trifluoromethyl)pyridine-3-sulfonyl chloride 
• 1246078-35-2 (1R)-(5-(2-bromo-5-fluorophenyl)-1-tert-butyl-1H-pyrazol-4-yl)(cyclopropyl)-methanamine 

Downstream Products

• 1246078-88-5 (R)-N-((1-tert-butyl-5-(3-fluorophenyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide 
• 1246078-76-1 (R)-1-tert-butyl-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES

The present invention provides methods, i.e., scalable or large-scale processes for the production of fused, tricyclic sulfonamido analogs, such as substituted or unsubstituted 5- (aryl-sulfonyl)-4,5-dihydro- 1H-pyrazolo[4,3-c]quinolines and 5-(heteroaryl-sulfonyl)-4,5- dihydro-1H-pyrazolo[4,3-c]quinolines. Exemplary methods of the invention include an intra-molecular cyclization step, in which a carbon-nitrogen bond is formed, and which employs a copper-based catalyst that contains at least one organic ligand, such as DMEDA. The invention further provides compounds, which are useful as intermediates in the methods of the invention.