1246090-51-6Relevant articles and documents
Synthesis of 2-[2,4-diaminothiazol-5-oyl]benzothiazoles
Rejia, T. F. Abbs Fen,Rajasekharan, Kallikat N.
experimental part, p. 994 - 997 (2010/10/21)
(Chemical Equation Presented) The synthesis of 2-(4-amino-2- alkylaminothiazol-5-oyl)benzothiazoles and 2-[2,4-bis(arylamino)thiazol-5-oyl] benzothiazoles as benzothiazoloylthiazole analogs of the cytotoxic marine alkaloid dendrodoine is reported. The highly decorated thiazole ring assembly was achieved using 2-bromoacetybenzothiazole to supply the C5 ring carbon and amidinothioureas of the type R1NH-CS-NH-C(=NHR2)-(NHR 3) to provide the four ring atoms [C4-N3-C2-S1] in a [4+1] thiazole ring construction strategy. The antibacterial activity of these new analogs is reported.