124611-69-4

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 1313741-48-8 1-phenyl-3-(thiophen-2-yl)-1,5,6,7-tetrahydro-4H-indazol-4-one 
• 1313741-50-2 1-(4-fluorophenyl)-3-(2-thienyl)-1,5,6,7-tetrahydro-4H-indazol-4-one 
• 1313741-52-4 2-(4-fluorophenyl)-3-(2-thienyl)-2,5,6,7-tetrahydro-4H-indazol-4-one 
• 1313741-49-9 1-(4-methoxyphenyl)-3-(2-thienyl)-1,5,6,7-tetrahydro-4H-indazol-4-one 
• 1313741-51-3 2-[(benzylhydrazono)(2-thienyl)methyl]-3-ethoxycyclohex-2-en-1-one 
• 1313741-54-6 3-hydroxy-2-[(hydroxyimino)(2-thienyl)methyl]cyclohex-2-en-1-one 
• 1313741-80-8 3-(2-thienyl)-6,7-dihydro-2,1-benzisoxazol-4(5H)-one 
• 169814-81-7 3-(2-thienyl)-6,7-dihydro-1,2-benzisoxazol-4(5H)-one 
• 124610-62-4 3-hydroxy-2-(2-thienylcarbonyl)cyclohex-2-en-1-one 

Relevant academic research and scientific papers

Novel synthesis of 2-thienylcarbonyl-cyclohexane-1,3-dione as building block for indazolones and isoxazolones

A new synthetic methodology using ultrasonic treatment was applied to the C-acylation of 1,3-cyclohexanedione with thiophene-2-carbonyl chloride to afford 3-hydroxy-2-(2-thienylcarbonyl)cyclohex-2-en-1-one (5). This compound was used as a building block to prepare different bicyclic systems: tetrahydro-4H- indazol-4-ones (7ac and 9a,b,d), and 6,7-dihydrobenzisoxazole (11) by reaction with different hydrazines and hydroxylamine, respectively. Structural elucidation of all compounds was thoroughly achieved by NMR spectroscopy. CSIRO 2011.