124612-15-3

Usage

Uses

Used in Pharmaceutical Industry:
5-(Trifluoromethyl)cyclohexane-1,3-dione is used as a building block for the preparation of various pharmaceuticals. Its unique structure and the presence of the trifluoromethyl group contribute to the development of new drugs with improved properties.
Used in Agrochemical Industry:
5-(Trifluoromethyl)cyclohexane-1,3-dione is also utilized in the synthesis of agrochemicals, serving as a key intermediate for the production of effective and environmentally friendly pesticides and other agricultural chemicals.
Used in Specialty Chemicals and Materials Production:
5-(Trifluoromethyl)cyclohexane-1,3-dione is used in the production of specialty chemicals and materials, where its unique properties can be leveraged to create innovative products with specific applications in various industries.
Used in Medicinal and Chemical Research:
5-(Trifluoromethyl)cyclohexane-1,3-dione is employed as a valuable compound in medicinal and chemical research, where its trifluoromethyl group can be explored for its potential to enhance the activity and selectivity of newly synthesized compounds.

Upstream product

• 25597-16-4 ethyl 4,4,4-trifluorocrotonate 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 1048703-55-4 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one 
• 1210418-38-4 3-oxo-5-(trifluoromethyl)cyclohex-1-en-1-yl trifluoromethanesulfonate 
• 1625672-14-1 1-((4-cyanophenyl)(2-hydroxy-6-oxo-4-(trifluoromethyl)cyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)phenyl)urea 
• 1625672-15-2 1-((4-cyanophenyl)(2-ethoxy-6-oxo-4-(trifluoromethyl)cyclohex-1-enyl)methyl)-3-(3-(trifluoromethyl)phenyl)urea 
• 1625669-42-2 4-(2,5-dioxo-7-(trifluoromethyl)-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)benzonitrile 

Relevant academic research and scientific papers

Design and development of trifluoromethylated enaminone derivatives as potential anticonvulsants

Enaminone derivatives have been widely studied as potential anticonvulsant agents to treat epilepsy. Our research group is focused on evaluating the anticonvulsant activities of cyclic enaminones connected to a substituted aromatic ring via a sp2 hybridized linker. We herein report our lead optimization efforts and the subsequent synthesis of the target fluorinated N-benzamide enaminone analog N-(3-oxo-5-(trifluoromethyl) cyclohex-1-en-1-yl)-4-(trifluoromethyl) benzamide (compound 7) from fluorinated intermediates, and its bioevaluation in acute seizure rodent models. The synthesis of the fluorinated cycloalkyl intermediates, 5-(trifluoromethyl) cyclohexane-1,3-dione (compound 5) and 3-amino-5-(trifluoromethyl) cyclohex-2-en-1-one (compound 6) were derived from an improve method of a one-pot hydrolysis and acid catalyzed decarboxylation of 4-carbo-tert-butoxy-5-trifluoromethylcyclohexane-1,3-dione (compound 4). Compound 7 produced pharmacological response at a higher dose of 300 mg/kg with only 25% protection observed, when compared to our previous lead compound THA40 in the 6 Hz 44 mA animal model. In the maximal electroshock (MES) model, compound 7 showed moderate activity at 100 mg/kg with 25% after 2 h. At a higher dose of 300 mg/kg, 25% of the animals were protected both at 0.5 h and 2 h. Although compound 7 did not produce the expected results, it allowed for a new avenue to investigate during our lead optimization studies.

Kinase inhibitors and methods of their use

New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.

Synthesis of 5-(trifluoromethyl)cyclohexane-1,3-dione and 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one: new trifluoromethyl building block

A simple synthesis of 5-(trifluoromethyl)cyclohexane-1,3-dione and 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one from the sodium salt of methyl or ethyl-4-hydroxy-2-oxo-6-(trifluoromethyl)cyclohex-3-en-1-oate is demonstrated. The compounds represent high