1246188-44-2

Basic information

• Product Name: 1-(3-chlorophenyl)-3-(1-propionylpiperidin-4-yl)urea
• CAS NO: 1246188-44-2
• Molecular Weight: 309.796
• Mol File: 1246188-44-2.mol

Chemical Properties

• CAS DataBase Reference: 1-(3-chlorophenyl)-3-(1-propionylpiperidin-4-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chlorophenyl)-3-(1-propionylpiperidin-4-yl)urea(1246188-44-2)
• EPA Substance Registry System: 1-(3-chlorophenyl)-3-(1-propionylpiperidin-4-yl)urea(1246188-44-2)

Safety Data

• Hazardous Substances Data: 1246188-44-2(Hazardous Substances Data)

Upstream product

• 2909-38-8 m-chlorophenyl isocyanate 
• 577778-40-6 1-(4-aminopiperidin-1-yl)propan-1-one 

Relevant articles and documents

Acyl piperidine inhibitors of soluble epoxide hydrolase

Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.

1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: Structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain

1,3-Disubstituted ureas possessing a piperidyl moiety have been synthesized to investigate their structure-activity relationships as inhibitors of the human and murine soluble epoxide hydrolase (sEH). Oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors in mice revealed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. For example, 1-(1-(cyclopropanecarbonyl) piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (52) showed a 7-fold increase in potency, a 65-fold increase in Cmax, and a 3300-fold increase in AUC over its adamantane analogue 1-(1-adamantyl)-3-(1-propionylpiperidin-4-yl) urea (2). This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.