1246199-63-2Relevant academic research and scientific papers
Click reaction in conjunction with diazeniumdiolate chemistry: Developing high-load nitric oxide donors
Oladeinde, Oyebola A.,Hong, Sam Y.,Holland, Ryan J.,MacIag, Anna E.,Keefer, Larry K.,Saavedra, Joseph E.,Nandurdikar, Rahul S.
supporting information; experimental part, p. 4256 - 4259 (2010/11/04)
Figure Presented. The use of Cu(I)-catalyzed click reactions of alkyne-substituted diazeniumdiolate prodrugs with bis- and tetrakis-azido compounds is described. The click reaction for the bis-azide using CuSO4/Na-ascorbate predominantly gave the expected bis-triazole. However, CuI/diisopropylethylamine predominantly gave uncommon triazolo-triazole products as a result of oxidative coupling. Neither set of click conditions showed evidence of compromising the integrity of the diazeniumdiolate groups. The chemistry developed has applications in the synthesis of polyvalent and dendritic nitric oxide donors.
