1246213-34-2 Usage
Uses
Used in Pharmaceutical Industry:
Methyl 2-(5-tert-butyl-2-hydroxy-4-nitrophenyl)-2-methylpropanoate is used as an intermediate in the synthesis of Ivacaftor Carboxylic Acid (I940605) for the development of Ivacaftor (I940600), a drug that aids in the treatment of cystic fibrosis. Its role in the synthesis process is crucial for producing a medication that helps improve the quality of life for patients suffering from this genetic disorder.
Additionally, as an impurity in Ivacaftor (I940600), it is essential to monitor and control the levels of methyl 2-(5-tert-butyl-2-hydroxy-4-nitrophenyl)-2-methylpropanoate during the manufacturing process to ensure the safety, efficacy, and quality of the final drug product. This is important because impurities can potentially affect the drug's performance or cause adverse effects in patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1246213-34-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,2,1 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1246213-34:
(9*1)+(8*2)+(7*4)+(6*6)+(5*2)+(4*1)+(3*3)+(2*3)+(1*4)=122
122 % 10 = 2
So 1246213-34-2 is a valid CAS Registry Number.
1246213-34-2Relevant academic research and scientific papers
PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
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Page/Page column 72-73, (2010/10/03)
The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
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Page/Page column 42-43, (2010/10/03)
This invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R is COOH or CH2OH.
