1246221-65-7

Basic information

• Product Name: methyl 3-benzyl-2-methyl-4-oxo-3,11b-dihydro-4H-pyrimido[6,1-a]isoquinoline-1-carboxylate
• CAS NO: 1246221-65-7
• Molecular Weight: 360.412
• Mol File: 1246221-65-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 3-benzyl-2-methyl-4-oxo-3,11b-dihydro-4H-pyrimido[6,1-a]isoquinoline-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-benzyl-2-methyl-4-oxo-3,11b-dihydro-4H-pyrimido[6,1-a]isoquinoline-1-carboxylate(1246221-65-7)
• EPA Substance Registry System: methyl 3-benzyl-2-methyl-4-oxo-3,11b-dihydro-4H-pyrimido[6,1-a]isoquinoline-1-carboxylate(1246221-65-7)

Safety Data

• Hazardous Substances Data: 1246221-65-7(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 72002-24-5 methyl 3-(benzylamino)but-2-enoate 
• 503-38-8 trichloromethyl chloroformate 

Relevant articles and documents

Synthesis of pyrimido[6,1-a]isoquinolines via a one-pot, four-component reaction

An efficient one-pot synthesis of pyrimido[6,1-a]isoquinoline-1-carboxylate derivatives is described. This involves the four-component reaction between primary amines, alkyl acetoacetates, isoquinoline and trichloromethylchloroformate (diphosgene) under mild conditions at ambient temperature. A facile and direct synthetic entry to pyrimido[6,1-a]isoquinolines via a one-pot, four-component reaction of primary amines and alkyl acetoacetates, isoquinoline and trichloromethylchloroformate (diphosgene) under mild conditions at ambient temperature is reported.