1246249-84-2

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 54166-95-9 2-amino-6-chlorobenzamide 
• 197638-78-1 4-(4-isopropylpiperazin-1-yl)benzaldehyde 
• 4318-42-7 1-(1-methylethyl)piperazine 
• 2148-56-3 2-chloro-6-aminobenzoic acid 

Relevant academic research and scientific papers

Anti-inflammatory agents

Disclosed are novel compounds that are useful in regulating the expression of interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1), and their use in the treatment and/or prevention of cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s). Also, disclosed are compositions comprising the novel compounds, as well as methods for their preparation.

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.