1246271-75-9Relevant academic research and scientific papers
Cobalt-catalyzed addition reaction of organoboronic acids with aldehydes: Highly enantioselective synthesis of diarylmethanols
Karthikeyan, Jaganathan,Jeganmohan, Masilamani,Cheng, Chien-Hong
, p. 8989 - 8992 (2010)
Predicted outcomes: The addition reaction of organoboronic acids with aldehydes in the presence of K2CO3 catalyzed by CoI 2/ACHTUNGRE(R,R)-BDPP gives chiral secondary alcohols in excellent yields with 90-99 % enantiomeric excess (see scheme; (R,R)-BDPP = (2R,4R)-(+)-2,4-bis(diphenyl-phosphino)pentane). This method provides an alternative to prepare an R and S enantiomeric pair by using the same chiral ligand and allows the stereochemical outcome of the reaction to be predicted.
METHOD FOR SYNTHESIS OF SECONDARY ALCOHOLS
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Page/Page column 2, (2012/06/16)
A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.
