124628-02-0

Basic information

• Product Name: 2-[1,4,7,10-tetraaza-4-(1-carboxy-2-benzyloxy-ethyl)-7,10-di(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid
• Synonyms: 2-[1,4,7,10-tetraaza-4-(1-carboxy-2-benzyloxy-ethyl)-7,10-di(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid
• CAS NO: 124628-02-0
• Molecular Weight: 644.722
• Mol File: 124628-02-0.mol

Chemical Properties

• CAS DataBase Reference: 2-[1,4,7,10-tetraaza-4-(1-carboxy-2-benzyloxy-ethyl)-7,10-di(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1,4,7,10-tetraaza-4-(1-carboxy-2-benzyloxy-ethyl)-7,10-di(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid(124628-02-0)
• EPA Substance Registry System: 2-[1,4,7,10-tetraaza-4-(1-carboxy-2-benzyloxy-ethyl)-7,10-di(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid(124628-02-0)

Safety Data

• Hazardous Substances Data: 124628-02-0(Hazardous Substances Data)

Upstream product

• 113933-16-7 2-bromo-3-(phenylmethoxy)propanoic acid methyl ester 
• 229312-34-9 1,4-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane 

Relevant articles and documents

1,4,7,10-tetraazacyclododecane-1,4-diacetic acid derivatives as chelating agents

Compounds of formula (I) in which R is in which R is hydrogen, a straight or branched or cyclic C1-C6alkyl group, unsubstituted or substituted by 1 to 10 oxygen atoms, or a C1-C20alkyl group, optionally interrupted by a phenylene, in turn substituted by a straight or branched C1-C6alkyl group, unsubstituted or substituted by 1 to 3 C1-C7alkyl groups; the phenylene group being unsubstituted or substituted by alkoxy, carboxy, sulfamoyl, hydroxyalkyl, amino groups; as well as its complexes with a bi- or trivalent metal ion having an atomic number from 20 to 31, 39, 42, 43, 44, 49, or from 57 to 83, as well as its salts with anions of physiologically acceptable organic acids chelated complexes of these compounds are used as contrast agents for nuclear magnetic resonance imaging.

1,4,7,10-tetraazacyclododecane-1,4-diacetic acid

1,4,7,10-tetraazacyclododecane-1,4-diacetic acid of formula (I): as well as its chelated complex salts with bi-valent metal ions having atomic numbers from 20 to 31, 39, 42, 43, 44, 49, or from 57 to 83, as well as their salts with anions of physiological

1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles

The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles. STR1

Macrocyclic chelating agents and chelates thereof

Macrocyclic derivatives of 1,4,7,10-tetraazacyclododecane of general formula (I) hereinbelow, wherein A is a group of formula (II) hereinbelow, in which R is H or alkyl or optionally substituted benzyl or a H(OCH2 CH2)1-4-, Me(OCH2 CH2)1-4-, or Et(OCH2 CH2)1-4- group, X or O--R1, in which R1 is H or alkyl, hydroxyalkyl, alkoxyalkyl, alkoxyhydroxyalkyl or a polyoxaalkyl group or X is --NR2 R3, in which R2 and R3 are H or alkyl, hydroxyalkyl, alkoxyalkyl or alkoxyhydroxyalkyl, and B1, B2 and B3 have the same meanings as A or are H or a group of formula (III) hereinbelow, in which R4 is H or alkyl, Y is a O--R5 group, wherein R5 is H or alkyl, hydroxyalkyl, alkoxyalkyl, alkoxyhydroxyalkyl or a polyoxaalkyl group, or Y is a --NR6 R7 group, wherein R6 and R7 are H or alkyl, hydroxyalkyl, alkoxyalkyl, or alkoxyhydroxyalkyl, said derivatives optionally being salified, and the complex salts thereof, are used as pharmaceuticals and/or diagnostic agents. STR1

Macrocyclic chelating agents and chelates thereof

Macrocyclic derivatives of 1,4,7,10-tetraazacyclo-dodecane of general formula I wherein, A is a group of formula in which, R is H or alkyl or optionally substituted benzyl or a H(OCH2CH2)1 4-, Me(OCH2CH2)1 4-, or Et(OCH2CH2)1 4- group,X is O-R1, in which R1 is H or alkyl, hydroxyalkyl, alko-xyalkyl, alkoxyhydroxyalkyl or a polyoxaalkyl group or X is -NR2R3, in which R2 and R3 are H or alkyl, hydroxyalkyl, alkoxyalkyl or alkoxyhydroxyalkyl,and, B1, B2 and B3 have the same meanings as A or are H or a group of formula in which, R4 is H or alkyl, Y is a O-R5 group, wherein R5 is H or alkyl, hydroxyalkyl, alkoxyalkyl, alkoxyhydroxyalkyl or a polyoxaalkyl group, or Y is a -NR6R7 group, wherein R6 and R7 are H or alkyl, hydroxyalkyl, alkoxyalkyl or alkoxyhydroxyalkyl, said derivatives optionally being salified, and the complex salts thereof, are used as pharmaceuticals and/or diagnostic agents.