Cas 1246366-45-9,C29H34FN5O5

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Check Digit Verification of cas no

The CAS Registry Mumber 1246366-45-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,3,6 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1246366-45:
(9*1)+(8*2)+(7*4)+(6*6)+(5*3)+(4*6)+(3*6)+(2*4)+(1*5)=159
159 % 10 = 9
So 1246366-45-9 is a valid CAS Registry Number.

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1246366-45-9Relevant academic research and scientific papers

Iminoheterocycles as γ-secretase modulators

Caldwell, John P.,Bennett, Chad E.,McCracken, Troy M.,Mazzola, Robert D.,Bara, Thomas,Buevich, Alexei,Burnett, Duane A.,Chu, Inhou,Cohen-Williams, Mary,Josein, Hubert,Hyde, Lynn,Lee, Julie,McKittrick, Brian,Song, Lixin,Terracina, Giuseppe,Voigt, Johannes,Zhang, Lili,Zhu, Zhaoning

, p. 5380 - 5384 (2010)

The synthesis of a novel series of iminoheterocycles and their structure-activity relationship (SAR) as modulators of γ-secretase activity will be detailed. Encouraging SAR generated from a monocyclic core led to a structurally unique bicyclic core. Selected compounds exhibit good potency as γ-secretase modulators, excellent rat pharmacokinetics, and lowering of Aβ42 levels in various in vivo models.

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