1246376-52-2Relevant academic research and scientific papers
Photodecarboxylative benzylations of phthalimide in pH 7 buffer: A simple access to 3-arylmethyleneisoindolin-1-ones
Belluau, Vincent,Noeureuil, Pierre,Ratzke, Elfrun,Skvortsov, Aleksei,Gallagher, Sonia,Motti, Cherri Ann,Oelgem?ller, Michael
experimental part, p. 4738 - 4741 (2010/10/02)
Photoadditions of phenylacetates to phthalimide in pH 7 buffer solution give the corresponding benzylated-hydroxyphthalimidines in moderate to high yields of up to 94%. In a micro-structured reactor, higher conversions and purities are achieved. With branched phenylacetates, photoaddition affords diastereoisomeric mixtures with low to moderate de values. Subsequent acid-catalyzed dehydration furnishes the corresponding 3- arylmethyleneisoindolin-1-ones in good to excellent yields and with high E-selectivities. Irradiation of the parent 3-phenylmethyleneisoindolin-1-one under oxidative conditions only leads to cis/trans-isomerization.
