1246434-44-5Relevant academic research and scientific papers
Reactions of substituted gem-dichlorocyclopropanes with phenols
Raskildina, Gulnara Z.,Aminova, Elmira K.,Kazakova, Anna N.,Bogomazova, Anna A.,Mikhailova, Natalia N.,Zlotsky, Simon S.
, p. 497 - 500 (2014/04/03)
By studying the reactions of substituted phenols with halomethyl-gem- dichlorocyclopropanes in dimethyl sulfoxide, concurrent for both endocyclic and exocyclic chlorine atoms, it was found that cis- and trans-1,1,3-trichloro-2- (chloromethyl)cyclopropanes react with phenols, producing 1,1-disubstituted (chloromethylen)cyclopropanes, as mixtures of Z- and E-configuration isomers, and 1,1-disubstituted 2-chloro-3-methylencyclopropanes. Cyclopropane ring cleaving was observed in reactions of phenols with 2-bromo-2-phenylgem- dichlorocyclopropane. The nature of the nucleophile has a significant effect on the yield of the reaction products.
