1246440-34-5Relevant academic research and scientific papers
Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity
Tanaka, Hiroshi,Tanaka, Yoshikazu,Minoshima, Masafumi,Yamaguchi, Sho,Fuse, Shinichiro,Doi, Takayuki,Kawauchi, Susumu,Sugiyama, Hiroshi,Takahashi, Takashi
supporting information; experimental part, p. 5942 - 5944 (2010/10/21)
The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.
