1246449-53-5Relevant academic research and scientific papers
Design synthesis and anti-proliferative activity of some new coumarin substituted hydrazide–hydrazone derivatives
Duangdee, Nongnaphat,Mahavorasirikul, Wiratchanee,Prateeptongkum, Saisuree
, (2020/04/29)
Abstract: A series of 21 coumarin hydrazide–hydrazone derivatives were designed, synthesized and evaluated potential cytotoxicity effects at 25 μg/mL for 48 h against liver cancer (HepG2) cell line in vitro. Then, seven out of 21 compounds with % cell via
Synthesis and antimicrobial activity of novel coumarin derivatives from 4-methylumbelliferone
Medimagh-Saidana, Sined,Romdhane, Anis,Daami-Remadi, Mejda,Jabnoun-Khiareddine, Haifa,Touboul, David,Jannet, Hichem Ben,Hamza, M'Hamed Ali
, p. 3247 - 3257 (2015/08/03)
Considering the potential interest of heterocyclic compounds, the aim of the present study is to synthesize new coumarin derivatives, to provide their full chemical characterization and to evaluate their antimicrobial activities. The reaction of ethyl 2-(4-methyl-2-oxo-2H-chromen-7-yloxy) acetate 2 with sodium hydroxide afforded the corresponding 2-(2-oxo-4-methyl-2H-chromen-7-yloxy) acetic acid 3 which was esterified using a series of alcohols in the presence of iodine to yield a new series of coumarin esters 4a-j. On the other hand, treatment of the key intermediate 2 with an aqueous solution of hydrazine in ethanol at reflux gave the corresponding hydrazide 5 which further converted into coumarin derivatives 6a-f and 7a-c by condensation with a series of aromatic aldehydes and cyclic anhydrides, respectively. The synthesized compounds were completely characterized by 1H NMR, 13C NMR, IR and HRMS. The antibacterial and antifungal activities of the new synthesized compounds were evaluated using the disc diffusion method and seemed to be significant.
Synthesis and antioxidant activity of some new coumarinyl-1,3-thiazolidine- 4-ones
Cacic, Milan,Molnar, Maja,Sarkanj, Bojan,Has-Schoen, Elizabeta,Rajkovic, Valentina
, p. 6795 - 6809 (2011/02/23)
A series of Schiff's bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7- yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3- yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their ant
