1246461-86-8

Upstream product

• 13958-98-0 3-bromo-4-cyanopyridine 
• 1521-51-3 rac-3-bromocyclohexene 
• 100-48-1 pyridine-4-carbonitrile 

Downstream Products

• 1290059-09-4 3-bromo-2-(cyclohex-2-en-1-yl)-5-iodoisonicotinonitrile 
• 1290059-10-7 ethyl 2-((5-bromo-4-cyano-6-(cyclohex-2-en-1-yl)-3-iodopyridin-2-yl)methyl)acrylate 

Relevant academic research and scientific papers

Selective and multiple functionalization of pyridines and alkaloids via Mg- and Zn-organometallic intermediates

Chemical equations presented. Quinine, nicotine, and related electron-rich amino-substituted pyridines were readily metalated using LiCl-solubilized TMP (2,2,6,6-tetramethylpiperidyl) bases in the presence of BF3· OEt2. A full pyridi

Highly selective metalations of pyridines and related heterocycles using new frustrated lewis pairs or tmp-zinc and tmp-magnesium bases with bf 3·oet2

(Figure Presented) Efficient and selective: Frustrated Lewis pairs based on BF3·OEt2 and LiCl-com-plexed tmpMg or tmpZn amides (tmp = 2,2,6,6-tetramethylpiperidyl) allow the efficient and regioselective metalation of various functionalized N heterocycles (see scheme for examples). Moreover, such metalations carried out in the presence or absence of BF 3·OEt2 enable a complete switch of regioselectivity, thus allowing complementary fuctionalization.