1246465-10-0

Basic information

• Product Name: (S)-N-((R)-1-(dibutylphosphoryl)-1-phenylethyl)-2-methylpropane-2-sulfinamide
• Synonyms: (S)-N-((R)-1-(dibutylphosphoryl)-1-phenylethyl)-2-methylpropane-2-sulfinamide
• CAS NO: 1246465-10-0
• Molecular Weight: 385.551
• Mol File: 1246465-10-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N-((R)-1-(dibutylphosphoryl)-1-phenylethyl)-2-methylpropane-2-sulfinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-((R)-1-(dibutylphosphoryl)-1-phenylethyl)-2-methylpropane-2-sulfinamide(1246465-10-0)
• EPA Substance Registry System: (S)-N-((R)-1-(dibutylphosphoryl)-1-phenylethyl)-2-methylpropane-2-sulfinamide(1246465-10-0)

Safety Data

• Hazardous Substances Data: 1246465-10-0(Hazardous Substances Data)

Upstream product

• 15754-54-8 dibutylphosphine oxide 
• 874291-45-9 (S)-2-methyl-N-(1-phenylethylidene)propane-2-sulfinamide 

Relevant articles and documents

Zinc-mediated asymmetric additions of dialkylphosphine oxides to α,β-unsaturated ketones and N -sulfinylimines

A catalyst was synthesized on the basis of Trosts dinuclear catalyst characterized by working well without pyridine in the present phospha-Michael reaction. Nevertheless, the presence of pyridine is still advantageous in the present system. The substrate scope was successfully extended to enones employing diallyl phosphine oxide as a nucleophile. Excellent yields and enantioselectivities (up to >99% ee) were achieved for a wide scope of enones employing the catalyst under mild conditions. The detailed reaction mechanism is also discussed herein. Finally, the unprecedented asymmetric additions of dialkylphosphine oxides to N-sulfinylimines were achieved by using Et 2Zn as a base.