1246465-49-5Relevant academic research and scientific papers
Design and synthesis of novel isoxazole-based HDAC inhibitors
Conti, Paola,Tamborini, Lucia,Pinto, Andrea,Sola, Laura,Ettari, Roberta,Mercurio, Ciro,De Micheli, Carlo
experimental part, p. 4331 - 4338 (2010/09/16)
A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check its participation in the coordinating process. New isoxazole-based histone deacetylase inhibitors structurally related to SAHA were designed and synthesized to check the participation of the isoxazole moiety in the Zn 2+coordination.
