1246472-33-2Relevant academic research and scientific papers
Asymmetric synthesis of dihydrofurans via organocatalytic domino michael-alkylation reaction
Feng, Juhua,Lin, Lili,Yu, Kunru,Liu, Xiaohua,Feng, Xiaoming
supporting information, p. 1305 - 1310 (2015/04/22)
The chiral N,N-dioxide C-PrPr2 has been developed as an efficient organocatalyst to catalyze the asymmetric domino Michael-alkylation reaction between cyclohexane-1,3-dione derivatives and bromonitrostyrenes. For dimedone, the corresponding bicyclic 2,3-dihydrofurans with two stereocenters were obtained in up to 99 % yield with 95:5 d.r. and 96 % ee. For prochiral 5-monosubstituted cyclohexane-1,3-diones, the desymmetrization reaction provided the bicyclic 2,3-dihydrofurans with three stereocenters in up to 90 % yield with 82:18 d.r. and 94 % ee.
β,β-Dinitrostyrenes in reactions with cyclohexane-1,3-diones
Trukhin,Sheremet,Berestovitskaya
experimental part, p. 2035 - 2038 (2011/01/10)
The Michael-type addition of dimedone and dihydroresorcinol to β,β-dinitrostyrenes occurs easily without a catalyst. The adducts cyclize into 3-aryl-2-nitro-2,3,4,5,6-hexahydrobenzofuran-4-ones under the action of triethylamine.
