1246472-55-8Relevant academic research and scientific papers
Metal- and Base-Free Room-Temperature Amination of Organoboronic Acids with N-Alkyl Hydroxylamines
Sun, Hong-Bao,Gong, Liang,Tian, Yu-Biao,Wu, Jin-Gui,Zhang, Xia,Liu, Jie,Fu, Zhengyan,Niu, Dawen
, p. 9456 - 9460 (2018/07/29)
We have found that readily available N-alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in the presence of trichloroacetonitrile. This amination reaction proceeds rapidly at room temperature and in the absence of added metal or base, it tolerates a remarkable range of functional groups, and it can be used in the late-stage assembly of two complex units.
ORGANOMETALLIC COMPOUND HAVING NITROGEN-CONTAINING HETEROCYCLIC CARBENE LIGAND, CATALYST COMPRISING THE SAME, AND METHOD FOR PRODUCING AMINE COMPOUND
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Paragraph 0181, (2016/10/10)
PROBLEM TO BE SOLVED: To provide a novel organometallic compound, a novel catalyst containing the organometallic compound having excellent functional group selectivity to produce an amine compound by a reductive amination reaction or a hydrogenation reaction of an imine or an iminium ion, and a novel method for producing an amine compound using the catalyst. SOLUTION: Provided is an organometallic compound represented by the following general formula (1). [Ar represents an aromatic compound and the like; Q represents a hydrido group and the like; M represents ruthenium, rhodium, and the like; R1 represents an electron withdrawing group; R2 to R6 each independently represent a C1-20 alkyl group and the like; n is an integer of 0 to 3; and A represents a nitrogen-containing saturated heterocyclic carbene and the like containing at least two nitrogen atoms]. COPYRIGHT: (C)2015,JPO&INPIT
Indirect and direct catalytic asymmetric reductive amination of 2-tetralone
Bondarev, Oleg,Bruneau, Christian
experimental part, p. 1350 - 1354 (2010/10/21)
Herein we report a one-pot catalytic asymmetric reductive amination of 2-tetralone. High-throughput screening of a small library of chiral ligands allowed us to perform the enantioselective hydrogenation of the intermediate enamine with up to 60% ee and a one-pot reaction with up to 47% enantiomeric excess of the desired amine.
