1246472-56-9

Upstream product

• 32851-50-6 benzyl(3,4-dihydronaphthalen-2-yl)amine 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

ORGANOMETALLIC COMPOUND HAVING NITROGEN-CONTAINING HETEROCYCLIC CARBENE LIGAND, CATALYST COMPRISING THE SAME, AND METHOD FOR PRODUCING AMINE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel organometallic compound, a novel catalyst containing the organometallic compound having excellent functional group selectivity to produce an amine compound by a reductive amination reaction or a hydrogenation reaction of an imine or an iminium ion, and a novel method for producing an amine compound using the catalyst. SOLUTION: Provided is an organometallic compound represented by the following general formula (1). [Ar represents an aromatic compound and the like; Q represents a hydrido group and the like; M represents ruthenium, rhodium, and the like; R1 represents an electron withdrawing group; R2 to R6 each independently represent a C1-20 alkyl group and the like; n is an integer of 0 to 3; and A represents a nitrogen-containing saturated heterocyclic carbene and the like containing at least two nitrogen atoms]. COPYRIGHT: (C)2015,JPO&INPIT

Indirect and direct catalytic asymmetric reductive amination of 2-tetralone

Herein we report a one-pot catalytic asymmetric reductive amination of 2-tetralone. High-throughput screening of a small library of chiral ligands allowed us to perform the enantioselective hydrogenation of the intermediate enamine with up to 60% ee and a one-pot reaction with up to 47% enantiomeric excess of the desired amine.