1246496-71-8

Basic information

• Product Name: (3S,6S)-[3-⁽²⁾H,6-⁽²⁾H]-1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3,6-dimethylpiperazine-2,5-dione
• Synonyms: (3S,6S)-[3-⁽²⁾H,6-⁽²⁾H]-1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3,6-dimethylpiperazine-2,5-dione
• CAS NO: 1246496-71-8
• Molecular Weight: 412.497
• Mol File: 1246496-71-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,6S)-[3-⁽²⁾H,6-⁽²⁾H]-1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3,6-dimethylpiperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,6S)-[3-⁽²⁾H,6-⁽²⁾H]-1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3,6-dimethylpiperazine-2,5-dione(1246496-71-8)
• EPA Substance Registry System: (3S,6S)-[3-⁽²⁾H,6-⁽²⁾H]-1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3,6-dimethylpiperazine-2,5-dione(1246496-71-8)

Safety Data

• Hazardous Substances Data: 1246496-71-8(Hazardous Substances Data)

Upstream product

• 1246496-58-1 (S)-[3-⁽²⁾H,6-⁽²⁾H₂]-1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-methylpiperazine-2,5-dione 
• 74-88-4 methyl iodide 

Downstream Products

• 21386-65-2 L-alanine-2-d1 

Relevant articles and documents

A stereoselective synthesis of α-deuterium-labelled (S)-α-amino acids

An atom-efficient and stereoselective synthesis has been developed for the preparation of α-2H-labelled (S)-α-amino acids, starting from a novel chiral diketopi-perazine scaffold. Efficient mono-alkylation of the chiral template afforded the (S)-substituted adducts with the nature of the electrophile significantly effecting the stereochemical outcome. Subsequent alkylation was totally selective producing the 1, 4-cis adduct as the sole diastereoisomer. The deprotection was carried out using cerium ammonium nitrate followed by acid hydrolysis affording the enantipure α-amino acids. Springer-Verlag 2010.