124655-06-7

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 124655-05-6 (S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 108-18-9 diisopropylamine 

Downstream Products

• 124655-07-8 (3R,5S)-tert-butyl 6-(tert-butyldiphenylsilyloxy)-3,5-dihydroxyhexanoate 
• 1138453-01-6 C₂₆H₃₈O₅Si 
• 124655-11-4 ((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Total synthesis of (-)-bitungolide F

An efficient total synthesis of (-)-bitungolide F (6) in 17 steps and 20.1% yield is described herein. Key steps involve a Myers asymmetric alkylation to introduce the C6 methyl with proper stereochemistry, a Claisen-like cyclization to construct the α,β-unsaturated β-lactone and a Julia-Kocienski olefination to assemble the conjugated diene moiety.

2,4,6-substituted phenol derivatives

A 2,4,6-substituted phenol having the formula (I): STR1 wherein X is S or CH2 ; R1 and R2 are the same or different from each other and each is a lower alkyl group; R3 is a group of the formula: STR2 in which R4 is hydrogen atom or a lower alkyl group; R5 and R6 are the same or different from each other and each is hydrogen atom, a lower alkyl group, or a phenyl group which may be substituted, or a pharmaceutically acceptable salt thereof is useful as an active agent in a pharmaceutical composition. The pharmaceutical composition comprises a therapeutically effective amount of a compound having the formula (I), as an effective ingredient, in association with a pharmaceutically acceptable substantially nontoxic carrier or excipient. The pharmaceutical composition can be useful in the treatment of lipemia of mammals. Additionally the compounds can be used as antiatherosclerotic agents and antilipenic agents.

Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor

HR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated.

Optically active 3-demethylmevalonic acid derivatives, and intermediates

A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I STR1 (3,5-dihydroxy carboxylic acid derivatives) or of the formula II STR2 (β-hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII STR3 in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.