124655-06-7Relevant articles and documents
Total synthesis of (-)-bitungolide F
Su, Yingpeng,Xu, Yanfen,Han, Junjie,Zheng, Jiyue,Qi, Jing,Jiang, Tuo,Pan, Xinfu,She, Xuegong
supporting information; experimental part, p. 2743 - 2749 (2009/09/05)
An efficient total synthesis of (-)-bitungolide F (6) in 17 steps and 20.1% yield is described herein. Key steps involve a Myers asymmetric alkylation to introduce the C6 methyl with proper stereochemistry, a Claisen-like cyclization to construct the α,β-unsaturated β-lactone and a Julia-Kocienski olefination to assemble the conjugated diene moiety.
Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor
Wess,Kesseler,Baader,Bartmann,Beck,Bergmann,Jendralla,Bock,Holzstein,Kleine,Schnierer
, p. 2545 - 2548 (2007/10/02)
HR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated.