1246551-25-6

Usage

Uses

Used in Pharmaceutical Research and Development:
Tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate is used as a research compound for its potential role in the development of new pharmaceuticals. Its unique molecular structure may offer novel interactions with biological targets, contributing to the discovery of new therapeutic agents.
Used in Organic Chemistry:
In the realm of organic chemistry, tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate is used as a reagent or intermediate in the synthesis of various organic compounds. Its specific functional groups may facilitate targeted chemical reactions, aiding in the creation of complex organic molecules.
Used in Academic Research:
Tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate is utilized in academic research to explore its chemical properties, reactivity, and potential applications. This may include studies on its stability, solubility, and interactions with other molecules, which could lead to a better understanding of its behavior and uses in different chemical contexts.
While the specific applications and industries for tert-butyl 3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate are still being explored, its presence in research and development suggests a promising future in various sectors, including but not limited to pharmaceuticals and organic chemistry.

Upstream product

• 1256815-07-2 di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate 
• 1256815-06-1 di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate 
• 143540-05-0 2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 129799-08-2 tert-butyl methyl piperazine-1,3-dicarboxylate 

Downstream Products

• 1002338-92-2 tert-butyl 2-(4-chlorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256816-01-9 tert-butyl 2-(4-cyanophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-98-1 tert-butyl 2-(4-(trifluoromethyl)phenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1002339-44-7 tert-butyl 2-(4-(methylsulfonyl)phenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256816-00-8 tert-butyl 2-(4-fluorophenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-93-6 C₁₉H₂₇N₃O₄ 
• 1256815-95-8 C₂₀H₂₉N₃O₅ 
• 1256815-96-9 tert-butyl 2-(3-cyanobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-94-7 C₁₉H₂₇N₃O₄ 
• 1256815-91-4 tert-butyl 2-(4-chlorobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-89-0 tert-butyl 2-(4-fluorobenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-92-5 tert-butyl 2-(4-methoxybenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-90-3 tert-butyl 2-(4-methylbenzyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-88-9 tert-butyl 2-benzylhexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 

Relevant academic research and scientific papers

DIHYDROPYRIMIDINYLTHIAZOLE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula: wherein R1, R2, X, Y and A are as described herein, compositions including the compounds and methods of using the compounds.

Convenient synthesis of novel 2-substituted imidazopyrazinone derivatives

Starting from commercially available piperazine-2-carboxylic acid, a series of novel 2-aryl and 2-benzyl substituted imidazopyrazinone were prepared. The intermediates 5a-g were obtained through facile Buchwald-Hartwig coupling reaction, and the effects of catalyst, base, and solvent on the coupling reaction were investigated. The optimal reaction conditions for the coupling reaction were PdCl2(dppf)=NaO-t-Bu=toluene. Taylor & Francis Group, LLC.

Synthesis, biological assay in vitro and molecular docking studies of new imidazopyrazinone derivatives as potential dipeptidyl peptidase IV inhibitors

A series of novel imidazopyrazinone derivatives were synthesized and evaluated with regard to their ability to inhibit dipeptidyl peptidase IV (DPP-IV) in vitro. Of these compounds (2R)-4-oxo-4-[2-(3-carbamoylbenzyl)- hexahydro-3-oxoimidazo [1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan- 2-amine fumaric acid (17h, IC50 = 78 nM) was shown to effectively inhibit the activity of the dipeptidyl peptidase IV enzyme. Molecular docking studies were also performed to illustrate the binding mode of compounds 15c and 17h. Favorable interactions were identified from the binding of inhibitor 15c with DPP-IV. By analogy to the binding mode of compound 15c, it seems that the introduction of a substituted benzyl moiety onto the imidazopyrazinone could remarkably improve the inhibitory activity of compound 17h.