1246552-68-0Relevant academic research and scientific papers
Synthesis, structure–activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators
Hirose, Wataru,Kato, Yoshihiro,Yamamoto, Takayoshi,Kassai, Momoe,Takata, Makoto,Hayashi, Shun,Arai, Yukiyo,Imai, Satoki,Yoshida, Kohzo
, p. 3866 - 3869 (2016)
The design, synthesis and SAR studies of novel 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators (NAMs) are presented in this letter. Starting from a HTS hit compound (1, IC50?=?477
