124656-55-9

Upstream product

• 124656-58-2 methyl 4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoate 
• 125402-87-1 4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoic acid 
• 124656-57-1 methyl 4-(5-carboethoxy-5-cyanopentyl)benzoate 
• 124656-56-0 methyl 4-<(4-methylsulfonyloxy)butyl>benzoate 
• 123910-86-1 4-(4-hydroxybut-1-ynyl)benzoic acid methyl ester 
• 123910-88-3 methyl 4-(4-hydroxybut-1-yl)benzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 124656-59-3 diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate 

Relevant academic research and scientific papers

A FACILE ROUTE TO "OPEN CHAIN" ANALOGUES OF DDATHF

N-benzoyl>-L-glutamic acid (7-DM-DDATHF, 18) is a representative of a new series of achiral analogues of the potent anticancer agent 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).Members of this "open chain" pyrimidine series, 18, 19, and 20, were synthesized via guanidine cyclization of 6, 7, and 8 to give the pyrimidines 9, 10, and 11.Ester hydrolysis, glutamate coupling and final saponification yielded the target compounds.

L-glutamic acid derivatives

Pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-(4-[4-(2,4-diamino-6-hydroxypyrimidin-5-yl)-butyl]-benzoyl)-L-glutamic acid.