124656-55-9

Basic information

• Product Name: N-[4-[4-[(2,6-Diamino-1,4-dihydro-4-oxopyrimidin)-5-yl]butyl]benzoyl]-L-glutamic acid
• Synonyms: 5,10-Dideazaacyclotetrahydrofolic acid;662U88;N-[4-[4-[(2,6-Diamino-1,4-dihydro-4-oxopyrimidin)-5-yl]butyl]benzoyl]-L-glutamic acid;N-[4-[4-[(2,6-Diamino-4-oxo-3,4-dihydropyrimidin)-5-yl]butyl]benzoyl]-L-glutamic acid
• CAS NO: 124656-55-9
• Molecular Formula: C₂₀H₂₅N₅O₆
• Molecular Weight: 431.44
• Mol File: 124656-55-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[4-[4-[(2,6-Diamino-1,4-dihydro-4-oxopyrimidin)-5-yl]butyl]benzoyl]-L-glutamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-[4-[(2,6-Diamino-1,4-dihydro-4-oxopyrimidin)-5-yl]butyl]benzoyl]-L-glutamic acid(124656-55-9)
• EPA Substance Registry System: N-[4-[4-[(2,6-Diamino-1,4-dihydro-4-oxopyrimidin)-5-yl]butyl]benzoyl]-L-glutamic acid(124656-55-9)

Safety Data

• Hazardous Substances Data: 124656-55-9(Hazardous Substances Data)

Upstream product

• 124656-58-2 methyl 4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoate 
• 125402-87-1 4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoic acid 
• 124656-57-1 methyl 4-(5-carboethoxy-5-cyanopentyl)benzoate 
• 124656-56-0 methyl 4-<(4-methylsulfonyloxy)butyl>benzoate 
• 123910-86-1 4-(4-hydroxybut-1-ynyl)benzoic acid methyl ester 
• 123910-88-3 methyl 4-(4-hydroxybut-1-yl)benzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 124656-59-3 diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate 

Relevant articles and documents

A FACILE ROUTE TO "OPEN CHAIN" ANALOGUES OF DDATHF

N-benzoyl>-L-glutamic acid (7-DM-DDATHF, 18) is a representative of a new series of achiral analogues of the potent anticancer agent 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).Members of this "open chain" pyrimidine series, 18, 19, and 20, were synthesized via guanidine cyclization of 6, 7, and 8 to give the pyrimidines 9, 10, and 11.Ester hydrolysis, glutamate coupling and final saponification yielded the target compounds.