1246610-77-4

Basic information

• Product Name: 6-amino-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 6-amino-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 1246610-77-4
• Molecular Weight: 256.264
• Mol File: 1246610-77-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 434.3±55.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 6-amino-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione(1246610-77-4)
• EPA Substance Registry System: 6-amino-1-(2-cyanobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione(1246610-77-4)

Safety Data

• Hazardous Substances Data: 1246610-77-4(Hazardous Substances Data)

Upstream product

• 1246610-78-5 3-(2-cyanoacetyl)-3-methyl-1-(2-cyanobenzyl)urea 
• 21236-97-5 3-methyl-6-aminouracil 

Downstream Products

• 1246610-74-1 2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile 

Relevant articles and documents

DPP-4 inhibitor with dual action mechanisms and application of DPP-4 inhibitor

The invention discloses a DPP-4 inhibitor with dual action mechanisms and application of the DPP-4 inhibitor, relates to the field of dipeptidyl peptidase IV inhibitor medicines and in particular relates to a DPP-4 inhibitor, a preparation method of a compound of formula I and medicinal application of the compound as a novel DPP-4 inhibitor, and particularly application of the inhibitor in preparing anti-diabetic medicines. In-vivo and in-vitro pharmacodynamic experiment results show that the compound of formula I has a remarkable inhibition function on DPP-4, has an excellent blood sugar reduction effect, and in addition has a relatively good action effect when being compared with similar medicines alogliptin and vildagliptin. Meanwhile, the compound disclosed by the invention is simple and short in preparation route, easy in raw material obtaining, simple in process, applicable to industrial large-scale production and very great in development prospect.