1246658-68-3Relevant academic research and scientific papers
Transition-Metal-Catalyst-Free Cross-Coupling Reaction of Secondary Propargylic Acetates with Alkenyl- and Arylboronic Acids
Ueda, Mitsuhiro,Nakakoji, Daiki,Morisaki, Takahiro,Ryu, Ilhyong
, p. 7040 - 7045 (2017)
A cross-coupling reaction between secondary propargylic acetates and alkenylboronic acids proceeded to give 1,4-enynes in good yields without addition of transition metal catalyst and base. This simple protocol was also applicable to arylboronic acids, which gave 3-arylated alkynes in good yields. The observed induction period suggested that the reaction of propargylic acetates and organoboronic acids was affected by the in-situ generated AcOH as a catalyst, which was confirmed by a separate experiment.
Pd-catalyzed three-component coupling of N-Tosylhydrazone, terminal alkyne, and Aryl halide
Zhou, Lei,Ye, Fei,Zhang, Yan,Wang, Jianbo
experimental part, p. 13590 - 13591 (2010/12/29)
A Pd-catalyzed three-component reaction of N-tosylhydrazone, terminal alkyne, and aryl halide follows a mechanism involving a sequence of Pd carbene migratory insertion-transmetalation-reductive elimination, leading to the formation of one sp2-sp3 C-C bond and one sp-sp 3 C-C bond.
