1246665-63-3Relevant academic research and scientific papers
Influence of the reaction conditions on the evolution of the michael addition of β-keto sulfones to α,β-unsaturated aldehydes
Aleman, Jose,Marcos, Vanesa,Marzo, Leyre,Ruano, Jose Luis Garcia
, p. 4482 - 4491 (2010)
We have studied the influence of different reaction conditions on the conjugated addition of β-keto sulfones to a,βunsaturated aldehydes catalyzed by silyl prolinol ethers. Small changes in the starting material and/or in the experimental protocol are able to produce significant variations in the structures of the final products. The high chemical versatility of the resulting Michael adducts make possible their use in a variety of tandem and one-pot reactions to afford polysubstituted cyclic products bearing multiple chiral centers.
