1246686-35-0Relevant academic research and scientific papers
Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N′-substituted-2,6-piperidinedione
Zhang, Xiaopan,Fang, Hao,Zhu, Huawei,Wang, Xuejian,Zhang, Lei,Li, Minyong,Li, Qianbin,Yuan, Yumei,Xu, Wenfang
, p. 5981 - 5987 (2010)
Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel APN inhibitors with 3-phenylalanyl-N′-substituted-2,6-piperidinedione scaffold. The results showed that compound 7c had the most potent inhibitory activity against APN with the IC50 value to 5.00 ± 3.17 μM, which could be used as the lead compound in the future for anticancer agent research.
