1246737-08-5

Basic information

• Product Name: (3R,4S)-trans-3-methyl-4-(4-bromophenyl)oxetan-2-one
• CAS NO: 1246737-08-5
• Molecular Weight: 241.084
• Mol File: 1246737-08-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,4S)-trans-3-methyl-4-(4-bromophenyl)oxetan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-trans-3-methyl-4-(4-bromophenyl)oxetan-2-one(1246737-08-5)
• EPA Substance Registry System: (3R,4S)-trans-3-methyl-4-(4-bromophenyl)oxetan-2-one(1246737-08-5)

Safety Data

• Hazardous Substances Data: 1246737-08-5(Hazardous Substances Data)

Upstream product

• 598-22-1 propanoyl bromide 
• 1122-91-4 4-bromo-benzaldehyde 

Relevant articles and documents

Catalytic asymmetric synthesis of trans-configured β-lactones: Cooperation of Lewis acid and ion pair catalysis

The development of the first trans-selective catalytic asymmetric [2+2] cyclocondensation of acyl halides with aliphatic aldehydes furnishing 3,4-disubstituted β-lactones is described. This work made use of a new strategy within the context of asymmetric dual activation catalysis: it combines the concepts of Lewis acid and organic aprotic ion pair catalysis in a single catalyst system. The methodology could also be applied to aromatic aldehydes and offers broad applicability (29 examples). The utility was further demonstrated by nucleophilic ringopening reactions that provide highly enantiomerically enriched anti-aldol products.