1246754-98-2Relevant academic research and scientific papers
Synthesis of chiral α-amino tertiary boronic esters by enantioselective hydroboration of α-arylenamides
Hu, Naifu,Zhao, Guoqing,Zhang, Yuanyuan,Liu, Xiangqian,Li, Guangyu,Tang, Wenjun
, p. 6746 - 6749 (2015)
The rhodium-catalyzed asymmetric hydroboration of α-arylenamides with BI-DIME as the chiral ligand and (Bpin)2 as the reagent yields for the first time a series of α-amino tertiary boronic esters in good yields and excellent enantioselectivities (up to 99% ee).
Chiral NHC/Cu(I)-catalyzed asymmetric hydroboration of aldimines: Enantioselective synthesis of α-Amido boronic esters
Zhang, Shu-Sheng,Zhao, Yi-Shuang,Tian, Ping,Lin, Guo-Qiang
, p. 437 - 442 (2013)
Non-Csymmetric (N-alkyl, N-aryl)-hybrid chiral NHC/Cu(I) complex catalyzed asymmetric hydroboration of N-benzoyl aldimines has been developed. The reaction proceeded smoothly at room temperature, giving α-amido boronic esters in excellent yields (up to 94
Inversion or retention? Effects of acidic additives on the stereochemical course in enantiospecific suzuki-miyaura coupling of α-(acetylamino) benzylboronic esters
Awano, Tomotsugu,Ohmura, Toshimichi,Suginome, Michinori
, p. 20738 - 20741 (2012/03/07)
The stereochemical course of the stereospecific Suzuki-Miyaura coupling of enantioenriched α-(acetylamino)benzylboronic esters with aryl bromides can be switched by the choice of acidic additives in the presence of a Pd/XPhos catalyst system. Highly enant
Stereospecific Suzuki-Miyaura coupling of chiral α-(Acylamino) benzylboronic esters with inversion of configuration
Ohmura, Toshimichi,Awano, Tomotsugu,Suginome, Michinori
supporting information; experimental part, p. 13191 - 13193 (2010/11/18)
The first invertive B-alkyl Suzuki-Miyaura coupling has been achieved. The coupling of enantioenriched α-(acylamino)benzylboronic esters with aryl bromides and chlorides took place efficiently in toluene at 80 °C in the presence of Pd(dba)2 (5 mol %), XPhos (10 mol %), K 2CO3 (3 equiv), and H2O (2 equiv). The reaction proceeded with inversion of configuration to give diarylmethanamine derivatives in high yields with high conservation of enantiomeric excesses.
