1246763-28-9Relevant academic research and scientific papers
Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists
Papanastasiou, Ioannis P.,Georgiadis, Markos-Orestis,Iliopoulos-Tsoutsouvas, Christos,Paronis, Carol A.,Brust, Christina A.,Tran, Ngan K.,Ji, Lipin,Ma, Xiaoyu,Wood, JodiAnne T.,Zvonok, Nikolai,Tong, Fei,Bohn, Laura M.,Nikas, Spyros P.,Makriyannis, Alexandros
, (2022/01/20)
In earlier work, we explored the SAR for the C3 side chain pharmacophore in the hexahydrocannabinol template represented by the drug nabilone, which resulted in the development of AM2389. In an effort for further optimization, we have merged features of n
Novel 1′,1′-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist
Nikas, Spyros P.,Alapafuja, Shakiru O.,Papanastasiou, Ioannis,Paronis, Carol A.,Shukla, Vidyanand G.,Papahatjis, Demetris P.,Bowman, Anna L.,Halikhedkar, Aneetha,Han, Xiuwen,Makriyannis, Alexandros
experimental part, p. 6996 - 7010 (2010/12/18)
In pursuit of a more detailed understanding of the structural requirements for the key side chain cannabinoid pharmacophore, we have extended our SAR to cover a variety of conformationally modified side chains within the 9-keto and 9-hydroxyl tricyclic st
