1246763-40-5Relevant academic research and scientific papers
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists
Jiang, Shan,Iliopoulos-Tsoutsouvas, Christos,Tong, Fei,Brust, Christina A.,Keenan, Catherine M.,Raghav, Jimit Girish,Hua, Tian,Wu, Simiao,Ho, Jo-Hao,Wu, Yiran,Grim, Travis W.,Zvonok, Nikolai,Thakur, Ganesh A.,Liu, Zhi-Jie,Sharkey, Keith A.,Bohn, Laura M.,Nikas, Spyros P.,Makriyannis, Alexandros
, p. 3870 - 3884 (2021/05/04)
We report the development of novel cannabinergic probes that can stabilize the cannabinoid receptors (CBRs) through tight binding interactions. Ligand design involves the introduction of select groups at a judiciously chosen position within the classical
Novel 1′,1′-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist
Nikas, Spyros P.,Alapafuja, Shakiru O.,Papanastasiou, Ioannis,Paronis, Carol A.,Shukla, Vidyanand G.,Papahatjis, Demetris P.,Bowman, Anna L.,Halikhedkar, Aneetha,Han, Xiuwen,Makriyannis, Alexandros
experimental part, p. 6996 - 7010 (2010/12/18)
In pursuit of a more detailed understanding of the structural requirements for the key side chain cannabinoid pharmacophore, we have extended our SAR to cover a variety of conformationally modified side chains within the 9-keto and 9-hydroxyl tricyclic st
