1246763-91-6Relevant articles and documents
Toward l-homo-DNA: Stereoselective de novo synthesis of β-L-erythro-hexopyranosyl nucleosides
Dalonzo, Daniele,Guaragna, Annalisa,Van Aerschot, Arthur,Herdewijn, Piet,Palumbo, Giovanni
, p. 6402 - 6410 (2010)
A novel route to 2′,3′-dideoxy-β-l-erythro-hexopyranosyl nucleosides equipped with a 1′-(N6-benzoyladenin-9-yl) or a 1′-(thymin-1-yl) moiety has been developed. Synthesis of the enantiopure sugar moiety was carried out by a de novo approach based on a domino reaction as the key step. N-Glycosidation was explored via either nucleobase-transfer mechanism (B = T) or in situ anomerization (B = A or T), affording target nucleosides with high overall stereoselectivity.