1246776-63-5Relevant academic research and scientific papers
A fragment-based in situ combinatorial approach to identify high-affinity ligands for unknown binding sites
Shelke, Sachin V.,Cutting, Brian,Jiang, Xiaohua,Koliwer-Brandl, Hendrik,Strasser, Daniel S.,Schwardt, Oliver,Kelm, Soerge,Ernst, Beat
supporting information; experimental part, p. 5721 - 5725 (2010/11/02)
[Figure Presented] In the lead: The title method for the identification of ligands is particularly useful for binding sites where little or no structural information is available. In a fragment-based approach, a suitable pair of first- and second-site ligands is identiled by NMR experiments. By applying a receptor-mediated in situ combinatorial approach, the two ligands are then linked to generate a new high-affinity lead structure (see picture).
