1246831-34-4Relevant academic research and scientific papers
Regio- and stereoselective intramolecular hydroalkoxylation of aromatic alkynols: an access to dihydroisobenzofurans under transition-metal-free conditions
Yu, Shu-Yan,Gao, Li-Hong,Wu, Jing-Xin,Lan, Hong-Bing,Ma, Yi,Yin, Zhi-Gang
, p. 3303 - 3310 (2020/04/27)
An efficient, transition-metal-free method to synthesize dihydroisobenzofuran derivatives via intramolecular hydroalkoxylation of aromatic alkynols with the promotion of cesium carbonate has been developed. The reaction proceeds regioselectively with exclusive formation of 5-exo-dig product, and only Z-isomer of the new generated double bond is observed. This new protocol features with milder reaction conditions, more convenient operation and satisfactory selectivities.
Efficient synthesis of isothiochromene derivatives by Pd-catalyzed hydrothiolation reaction
Feng, Jie,Lv, Meifang,Lu, Guoping,Cai, Chun
supporting information, p. 5312 - 5317 (2014/10/15)
An efficient method for the preparation of isothiochromene derivatives through the palladium-catalyzed intramolecular hydrothiolation reaction of halides and thiourea is reported. Two carbon-sulfur bonds are formed in this one-pot palladium-catalyzed cascade reaction. This new protocol is free from foul-smelling thiols and operates under mild conditions to give isothiochromene derivatives in excellent yields and with excellent 6-endo-dig selectivity. Copyright
Regioselective synthesis and evaluation of 3-alkylidene-1, 3-dihydroisobenzofurans as potential antidepressant agents
Praveen,Iyyappan,Girija,Kumar, K Suresh,Perumal
body text, p. 451 - 462 (2012/08/07)
3-Alkylidene-1,3-dihydroisobenzofurans exhibited moderate antidepressant activity as evaluated by forced swim and tail suspension test methods. Virtual screening was carried out by docking the designed compounds into the serotonin binding sites of arabinase protein to predict the analogue binding mode of the compounds to the SSRIs. [Figure not available: see fulltext.]
